blue light PDT

Parkwood skin clinic

Photodynamic Therapy

Photodynamic Therapy (PDT) is a gentle and effective treatment that uses light and a special photosensitizing solution to tackle abnormal cells. It’s commonly used to treat skin cancer, precancerous spots, and even conditions like acne. The process is straightforward: a solution is applied to the problem area, and when exposed to a specific type of light, it activates a reaction that destroys the unwanted cells. What makes PDT special is its ability to precisely target the affected cells while keeping the surrounding healthy skin safe and intact.

cream that will be apply on the skin

What is Photodynamic Therapy?

Photodynamic Therapy (PDT) is a gentle yet powerful treatment for skin cancer that uses light and a special solution to precisely target cancer cells. The process starts with applying a photosensitizing agent to the affected area, which is absorbed mostly by the cancer cells. After allowing time for the solution to settle, the area is exposed to a specific type of light, often blue light. This light activates the agent, triggering a chemical reaction that creates reactive oxygen molecules. These molecules work to break down and destroy the cancer cells while leaving the surrounding healthy tissue unharmed. This precise and non-invasive method makes PDT an effective option for treating various types of skin cancers and abnormal cells.

When can you use photodynamic therapy?

Photodynamic Therapy (PDT) is a versatile treatment primarily indicated for skin conditions where targeted destruction of abnormal cells is needed while sparing healthy tissue. One of its most common uses is in the treatment of actinic keratosis, precancerous lesions caused by prolonged sun exposure, which, if left untreated, may develop into squamous cell carcinoma. PDT is also an effective option for superficial basal cell carcinoma, a type of non-melanoma skin cancer, especially for patients seeking a non-invasive alternative to surgery. By precisely targeting and destroying abnormal cells, PDT minimizes scarring and is often chosen for lesions in cosmetically sensitive areas like the face or scalp

Beyond cancerous and precancerous lesions, PDT is also used for treating moderate-to-severe acne and certain other inflammatory skin conditions. In acne treatment, PDT targets the sebaceous glands and the bacteria responsible for breakouts, helping to reduce active acne and prevent future flare-ups. It can also be employed to improve the appearance of sun-damaged skin, reducing redness, discoloration, and rough texture. With its ability to selectively target affected areas, PDT offers a safe, effective solution for a range of skin conditions, particularly for patients seeking minimal downtime and maximal precision.

core mechanisms of Photodynamic Therapy (PDT)

Photodynamic Therapy (PDT) involve the interaction of three key components: a photosensitizing agent, a specific wavelength of light, and oxygen in the tissue. These elements work together to selectively destroy abnormal or diseased cells while minimizing damage to surrounding healthy tissue. The process can be broken down into three main stages:

Photosensitizing Agent Application

A photosensitizing agent, such as 5-aminolevulinic acid (ALA) or methyl aminolevulinate (MAL), is applied to the targeted area. This agent is preferentially absorbed by rapidly dividing or abnormal cells, such as cancerous or precancerous cells, where it accumulates and becomes activated.

Light Activation

After the photosensitizer has been absorbed by the abnormal cells, the area is exposed to a specific wavelength of light (e.g., blue, red, or laser light). The light’s wavelength is carefully chosen to match the activation spectrum of the photosensitizing agent, ensuring that only the treated area is affected.

Reactive Oxygen Species Production

When the light activates the photosensitizing agent, it triggers a photochemical reaction that generates reactive oxygen species (ROS), such as singlet oxygen. These ROS cause direct damage to cellular components, including the cell membrane, proteins, and DNA, leading to the destruction of the abnormal cells.

blue light PDT vs Daylight PDT

Understanding the Differences

Photodynamic Therapy (PDT) can be delivered using different light sources, with blue light PDT and daylight PDT being two common options. Blue light PDT involves the use of a controlled, specific wavelength of blue light to activate the photosensitizing agent applied to the skin. This method is conducted in a clinical setting, providing precise and focused activation of the treatment area. Blue light PDT is ideal for patients with moderate to severe lesions, such as actinic keratosis, as it allows the doctor to carefully monitor the treatment and minimise unnecessary exposure. However, the procedure can cause a temporary burning sensation during light activation, which some patients may find uncomfortable.

Daylight PDT, on the other hand, harnesses natural sunlight to activate the photosensitising agent, making it a more convenient and less painful option for patients. This method is typically used for milder cases of actinic keratosis and is conducted outdoors under specific conditions to ensure effective light activation. Daylight PDT is less intense, often resulting in fewer side effects, such as redness and discomfort, but may require longer exposure times compared to blue light PDT. The choice between these methods depends on the patient’s condition, comfort level, and preference, with both offering effective treatment outcomes when tailored to the individual’s needs.

Photodynamic Therapy for Skin Cancer

Effective and Tailored Care

Photodynamic Therapy (PDT) is a targeted treatment for skin cancer, including actinic keratosis and superficial basal cell carcinoma. This minimally invasive approach uses a photosensitizing agent and light to selectively destroy cancerous cells while preserving healthy tissue, making it ideal for sensitive areas like the face. Most patients require one to two treatment sessions, depending on the size, depth, and number of lesions, with each session spaced a few weeks apart. PDT provides effective cancer management with minimal scarring and downtime, offering a precise and patient-friendly solution.

measurement of a superficial skin cancer

Co2 laser combined with Photodynamic therapy (PDT)

A Powerful Combination

Combining CO2 Laser with Photodynamic Therapy (PDT) is a transformative approach to treating advanced skin conditions such as severe sun damage, precancerous lesions, and stubborn acne scars. The CO2 laser precisely resurfaces the skin by removing its outermost layers, enhancing the absorption and effectiveness of the photosensitizing agent used in PDT. Together, these treatments address both surface-level and deeper skin concerns, stimulating collagen production and cellular renewal. This dual approach can lead to more dramatic, long-lasting results, improving skin texture, tone, and even tackling deeper lesions that may not respond fully to standalone treatments.

While this combination treatment offers significant benefits, it does come with increased risks, such as prolonged redness, swelling, and discomfort, with rare possibilities of scarring or infection. Strict post-procedure care, including avoiding sun exposure, is essential to minimize these side effects and ensure optimal healing. If you’re considering this intensive therapy, it’s vital to consult with an experienced professional to determine whether it’s the right option for your skin type and condition. With the right guidance, the combination of CO2 laser and PDT can deliver remarkable improvements and renewed skin confidence.

red light PDT

The ideal candidate

Photodynamic Therapy (PDT) is a minimally invasive treatment ideal for targeting specific skin conditions. It’s best suited for:

  • Individuals with precancerous lesions like actinic keratosis.
  • Patients with early-stage, superficial skin cancers such as basal cell carcinoma.
  • Those with sun-damaged skin seeking effective treatment with cosmetic benefits.
  • People with moderate-to-severe acne or inflammatory skin conditions, benefiting from PDT’s ability to reduce oil production and kill acne-causing bacteria.

Important Considerations:

  • Candidates must avoid sunlight and bright indoor light for at least 48 hours post-treatment to prevent photosensitivity reactions.
  • PDT is not suitable for individuals with conditions like lupus, porphyria, or a history of photosensitivity, as well as those who are pregnant or breastfeeding.

risks & complications

Photodynamic Therapy (PDT) is generally safe and well-tolerated, but like any medical procedure, it comes with potential risks and complications. Common side effects include redness, swelling, and peeling in the treated area, which typically subside within a few days to weeks. Patients may also experience a burning, stinging, or tingling sensation during the light activation phase, which is usually temporary but can be uncomfortable for some individuals. After the procedure, treated skin may appear darker (hyperpigmentation) or lighter (hypopigmentation) than the surrounding tissue, particularly in patients with darker skin tones.

Other, less common complications include infection at the treatment site, which can usually be prevented with proper wound care, and scarring, though this is rare. Some individuals may experience an exaggerated sensitivity to sunlight or indoor lighting (photosensitivity) in the days following treatment, leading to potential skin irritation or burns if exposed to UV light. Severe reactions, such as ulceration or prolonged healing, are very rare but may occur, particularly in individuals with sensitive or compromised skin. 

laser probe

crafting your treatment plan

At Parkwood Skin Clinic, your journey to healthier, more radiant skin is a deeply personalized and comfortable experience, guided by Dr. Gilles Laur. From the moment you step into our welcoming clinic, you’ll feel at ease in a relaxed setting designed with your comfort in mind. Dr. Laur takes the time to truly listen to your concerns and understand your unique skin needs, ensuring that every aspect of your care is tailored to you. This one-on-one attention fosters an intimate, collaborative experience where your goals are the priority, and no question is left unanswered.

Crafting your treatment plan is a thoughtful process, combining Dr. Laur’s vast knowledge and cutting-edge techniques with your individual preferences and lifestyle. Whether addressing medical concerns like skin cancer or achieving aesthetic goals, Dr. Laur ensures your plan is both effective and minimally invasive, offering the best outcomes with minimal downtime. Using advanced tools and treatments, he creates a clear path to achieving your desired results while maintaining the health and integrity of your skin. At Parkwood Skin Clinic, you’re not just a patient—you’re a partner in a journey to renewed confidence and glowing skin.

We Will Help You Every Step Of The Way

over 15 years of medical experience